Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins, found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Belongs to the immunoglobulin superfamily, CEA family- contains 7 Ig-like (immunoglobulin-like) domains.
| Inventor | Institute |
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| Lindy Durrant | University of Nottingham |
| SKU: | 153384 |
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| Product description: | Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins, found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Belongs to the immunoglobulin superfamily, CEA family- contains 7 Ig-like (immunoglobulin-like) domains. |
| Alternate name: | CEACAM5; CEA |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | CEA preparation purified from colon carcinoma metastases. Tumor subcellular membranes or viable cells from CEA-producing colon carcinoma cell lines |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Cat. #: | 153384 |
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| Provenance and Ownership: | The Anti-CEA/NCA 198 is owned by Cancer Research UK. CancerTools supplies the Anti-CEA/NCA 198 under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-CEA/NCA 198 directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer; Cell signaling and signal transduction |
| Application: | FACS ; IHC |
| Target: | CEA/NCA |
| Reactivity: | Human |
| Clone: | 198 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins, found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Belongs to the immunoglobulin superfamily, CEA family- contains 7 Ig-like (immunoglobulin-like) domains. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Reiterer et al. 2007. Cancer Res. 67(16):7765-72. PMID: 17699781. Platelet-derived growth factor receptor regulates myeloid and monocytic differentiation of HL-60 cells. Byers et al. 1988. J Immunol. 140(11):4050-5. PMID: 2453564. Potentiation of anti-carcinoembryonic antigen immunotoxin cytotoxicity by monoclonal antibodies reacting with co-expressed carcinoembryonic antigen epitopes. |
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