Anti-Cdk1 [Y100.4]

Cdk1 (Cdc2) is a serine/threonine kinase which forms complexes with cyclins A and B which then phosphorylate a variety of target substrates to enable cell cycle progression. Therefore, Cdk1 is a marker for proliferating tumour cells.

Contributors

Inventor Institute
Julian Gannon Cancer Research UK, London Research Institute: Clare Hall Laboratories
SKU: 151185
Product description: Cdk1 (Cdc2) is a serine/threonine kinase which forms complexes with cyclins A and B which then phosphorylate a variety of target substrates to enable cell cycle progression. Therefore, Cdk1 is a marker for proliferating tumour cells.
Alternate name: Cyclin-Dependent Kinase 1; Cell Division Cycle 2, G1 To S And G2 To M; Cell Division Control Protein 2 Homolog; Cell Division Protein Kinase 1; P34 Protein Kinase; P34CDC2; CDC28A; CDC2; Cell Cycle Controller CDC2; CDKN1
Conjugation: Unconjugated
Isotype: IgG2b
Immunogen: Peptide spanning the C-terminal 14 residues of S. pombe Cdk1.
Myeloma used: Sp2/0-Ag14
Cat. #: 151185
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer; Cell biology; Neurobiology
Application: WB ; WB
Target: Cyclin Dependent Kinase 1 (Cdk1, Cdc2)
Reactivity: Schizosaccharomyces pombe
Clone: Y100.4
Host: Mouse
Class: Monoclonal
Target background: Cdk1 (Cdc2) is a serine/threonine kinase which forms complexes with cyclins A and B which then phosphorylate a variety of target substrates to enable cell cycle progression. Therefore, Cdk1 is a marker for proliferating tumour cells.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Mennie et al. 2018. Nat Commun. 9(1):586. PMID: 29422503.

Chang et al. 2013. PLoS Genet. 9(11):e1003936. PMID: 24244195.

Fission yeast shelterin regulates DNA polymerases and Rad3(ATR) kinase to limit telomere extension.

Radcliffe et al. 1998. Mol Biol Cell. 9(7):1757-71. PMID: 9658169.

Identification of novel temperature-sensitive lethal alleles in essential beta-tubulin and nonessential alpha 2-tubulin genes as fission yeast polarity mutants.

Yamano et al. 1996. EMBO J. 15(19):5268-79. PMID: 8895572.

The role of proteolysis in cell cycle progression in Schizosaccharomyces pombe.

Images

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Adapted from Chang et al. 2013. PLoS Genet. 9(11)

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