Anti-Cdc6 [cdc6 9H8/5]

Cdc6 is essential for assembling the pre-replicative complex that forms at origins of DNA replication in the G1 phase of the cell cycle in budding yeast (S. cerevisiae).

Contributors

Institute
Cancer Research UK, London Research Institute: Clare Hall Laboratories
Cat. #: 151190
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell biology;Genetics
Application: IHC ; IP ; WB
Target: Cell-division cycle protein 6 (cdc6)
Reactivity: Saccharomyces cerevisiae
Clone: cdc6 9H8/5
Host: Mouse
Class: Monoclonal
Alternate name: Cell Division Cycle 6; Cdc18-Related Protein; CDC6-Related Protein; P62(Cdc6); HsCDC18; CDC18L; HsCDC6; CDC6 Cell Division Cycle 6 Homolog
Product description: Cdc6 is essential for assembling the pre-replicative complex that forms at origins of DNA replication in the G1 phase of the cell cycle in budding yeast (S. cerevisiae).
Conjugation: Unconjugated
Isotype: IgG1
Immunogen: cdc6 from S.Cerevisiae.
Target background: Cdc6 is essential for assembling the pre-replicative complex that forms at origins of DNA replication in the G1 phase of the cell cycle in budding yeast (S. cerevisiae).
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Evrin et al. 2013. Nucleic Acids Res. 41(5):3162-72. PMID: 23376927.

A yeast GSK-3 kinase Mck1 promotes Cdc6 degradation to inhibit DNA re-replication.

Ikui et al. 2012. PLoS Genet. 8(12):e1003099. PMID: 23236290.

Zhang et al. 2007. Cancer Res. 67(8):3827-34. PMID: 17440097.

Tumor necrosis factor receptor 1/c-Jun-NH2-kinase signaling promotes human neoplasia.

Perkins et al. 2001. EMBO J. 20(17):4836-45. PMID: 11532947.

Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis.

Donovan et al. 1997. Proc Natl Acad Sci U S A. 94(11):5611-6. PMID: 9159120.

Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast.

Images

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Adapted from Ikui et al. 2012. PLoS Genet. 8(12)

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