Anti-Cdc13 [6F11/2]
6F11/2 can be used for detecting Cdc13 and associated Cdk1 kinase activation.
Contributors
| Inventor | Institute |
|---|---|
| Jacqueline Hayles | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| SKU: | 151061 |
|---|---|
| Product description: | 6F11/2 can be used for detecting Cdc13 and associated Cdk1 kinase activation. |
| Alternate name: | Cell division control protein 13; YDL22C |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Immunogen: | Full length cdc13 |
| Myeloma used: | Sp2/0-Ag14 |
| Cat. #: | 151061 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Genetics |
| Application: | WB ; IHC ; IP ; WB |
| Target: | Cell-division cycle protein 13 (cdc13) |
| Reactivity: | Schizosaccharomyces pombe |
| Clone: | 6F11/2 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Cdc13 is a fission yeast (S. pombe) B-type M-phase cyclin. Cdc13 binds to Cdk1 (cdc2), and the resulting Cdk1-Cdc13 complex controls the G2/M transition of the cell cycle. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Rothe et al. 2017. J Cell Sci. 130(23):4028-4037. PMID: 29046339. Koch et al. 2012. ACS Chem Biol. 7(4):723-31. PMID: 22264160. A chemical genetic approach for covalent inhibition of analogue-sensitive aurora kinase. Okuzaki et al. 2010. Cell Cycle. 9(18):3751-60. PMID: 20855961. Spo5 phosphorylation is essential for its own timely degradation and for successful meiosis in Schizosaccharomyces pombe. Decottignies et al. 2001. J Cell Sci. 114(Pt 14):2627-40. PMID: 11683390. In vivo localisation of fission yeast cyclin-dependent kinase cdc2p and cyclin B cdc13p during mitosis and meiosis. |
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Adapted from Koch et al. 2012. ACS Chem Biol; 7(4)
