Anti-CD56 [123C3]

CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. Although CD56 is often considered a marker of neural lineage commitment due to its discovery site, CD56 expression is also found in, among others, the hematopoietic system. Here, the expression of CD56 is most stringently associated with, but certainly not limited to, natural killer cells.

Contributors

Institute
Netherlands Cancer Institute
SKU: 154738
Product description: CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. Although CD56 is often considered a marker of neural lineage commitment due to its discovery site, CD56 expression is also found in, among others, the hematopoietic system. Here, the expression of CD56 is most stringently associated with, but certainly not limited to, natural killer cells. CD56 has been detected on other lymphoid cells, including gamma delta (Î?δ) Τ cells and activated CD8+ T cells, as well as on dendritic cells. CD56 has been implicated as having a role in cell–cell adhesion, neurite outgrowth, synaptic plasticity, and learning and memory.
Alternate name: NCAM1; Neural Cell Adhesion Molecule 1
Conjugation: Unconjugated
Isotype: IgG1
Molecular weight: 140 kDa
Immunogen: Human small cell lung cancer membrane fraction
Cat. #: 154738
Tool sub type: Primary antibody
Unit size: 100 ug
Application: IHC ; IF ; IP
Target: CD56
Reactivity: Human
Host: Mouse
Class: Monoclonal
Target background: CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. Although CD56 is often considered a marker of neural lineage commitment due to its discovery site, CD56 expression is also found in, among others, the hematopoietic system. Here, the expression of CD56 is most stringently associated with, but certainly not limited to, natural killer cells. CD56 has been detected on other lymphoid cells, including gamma delta (?d) cells and activated CD8+ T cells, as well as on dendritic cells. CD56 has been implicated as having a role in cellcell adhesion, neurite outgrowth, synaptic plasticity, and learning and memory.
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Kibbelaar et al. 1991. Eur J Cancer. 27(4):431-5. PMID: 1851619.

Moolenaar et al. 1990. Cancer Res. 50(4):1102-6. PMID: 2153450.

Hilkens et al. 1984. Int J Cancer. 34(2):197-206. PMID: 6206003.

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