CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. Although CD56 is often considered a marker of neural lineage commitment due to its discovery site, CD56 expression is also found in, among others, the hematopoietic system. Here, the expression of CD56 is most stringently associated with, but certainly not limited to, natural killer cells.
| Institute |
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| Netherlands Cancer Institute |
| SKU: | 154738 |
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| Product description: | CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. Although CD56 is often considered a marker of neural lineage commitment due to its discovery site, CD56 expression is also found in, among others, the hematopoietic system. Here, the expression of CD56 is most stringently associated with, but certainly not limited to, natural killer cells. CD56 has been detected on other lymphoid cells, including gamma delta (ÄÂ?ÄÂĂ´) ÄÂä cells and activated CD8+ T cells, as well as on dendritic cells. CD56 has been implicated as having a role in cellÄËĂÂĂÂcell adhesion, neurite outgrowth, synaptic plasticity, and learning and memory. |
| Alternate name: | NCAM1; Neural Cell Adhesion Molecule 1 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 140 kDa |
| Immunogen: | Human small cell lung cancer membrane fraction |
| Cat. #: | 154738 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Application: | IHC ; IF ; IP |
| Target: | CD56 |
| Reactivity: | Human |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. Although CD56 is often considered a marker of neural lineage commitment due to its discovery site, CD56 expression is also found in, among others, the hematopoietic system. Here, the expression of CD56 is most stringently associated with, but certainly not limited to, natural killer cells. CD56 has been detected on other lymphoid cells, including gamma delta (?d) cells and activated CD8+ T cells, as well as on dendritic cells. CD56 has been implicated as having a role in cellcell adhesion, neurite outgrowth, synaptic plasticity, and learning and memory. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Kibbelaar et al. 1991. Eur J Cancer. 27(4):431-5. PMID: 1851619. Moolenaar et al. 1990. Cancer Res. 50(4):1102-6. PMID: 2153450. Hilkens et al. 1984. Int J Cancer. 34(2):197-206. PMID: 6206003. |
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