Anti-CD49e [SNAKA51]

CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain.

Contributors

Inventor Institute
Martin Humphries University of Manchester
SKU: 152487
Product description: CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor that is known variously: in lymphocytes as very late (activation) antigen 5 (VLA5); in platelets as glycoprotein IcIIa; and in fibroblasts as extracellular matrix receptor 6 (ECM…
Alternate name: Integrin Subunit Alpha 5; Fibronectin Receptor Subunit Alpha; CD49 Antigen-Like Family Member E; Integrin Alpha-F; VLA-5; FNRA; Very Late Activation Protein 5; Alpha Subunit; Fibronectin Receptor; Alpha Polypeptide; Fibronectin Receptor; Alpha Subunit; Fibronectin Receptor; Alpha Polypeptide; Integrin Alpha; CD49e Antigen; CD49e; VLA5A
Conjugation: Unconjugated
Isotype: IgG2a kappa
Immunogen: Whole cells corresponding to human Integrin alpha5.
Myeloma used: P3X63Ag8.653
Cat. #: 152487
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Apoptosis and autophagy;Cell biology;Cell signaling and signal transduction;Immunology
Application: IF ; Fn ; WB
Target: Integrin alpha5 (CD49e)
Reactivity: Human
Clone: SNAKA51
Host: Mouse
Class: Monoclonal
Target background: CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor that is known variously: in lymphocytes as very late (activation) antigen 5 (VLA5); in platelets as glycoprotein IcIIa; and in fibroblasts as extracellular matrix receptor 6 (ECM…
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Valdembri et al. 2009. PLoS Biol. 7(1):e25. PMID: 19175293.

Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells.

Clark et al. 2005. J Cell Sci. 118(Pt 2):291-300. PMID: 15615773.

A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation.

Images

View Gallery
Immunofluorescence on endothelial cells transfected with mNrp1-mRFP and Rab5-GFP and then incubated with anti-CD49e [SNAKA51]. mNrp1-mRFP and active a5b1 colocalize into Rab5-GFP-positive early endosomes as shown in merging (arrowheads). Lower panels are magnifications of the boxed areas shown in the upper panels. Taken from Valdembri et al. 2009. PLoS Biol. 7(1)

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