2B11 is widely used, in conjunction with the CD45RB antibody PD7/26, to detect white cell-derived tumours in paraffin sections.
| Inventor | Institute |
|---|---|
| Karen Pulford | University of Oxford |
| SKU: | 151361 |
|---|---|
| Product description: | 2B11 is widely used, in conjunction with the CD45RB antibody PD7/26, to detect white cell-derived tumours in paraffin sections. |
| Alternate name: | Protein Tyrosine Phosphatase Receptor Type C (PTPRC); L-CA; T2; Polypeptide; T2 Leukocyte Common Antigen; Leukocyte Common Antigen; T2 Glycoprotein; GP18; CD45R; B22; LCA; LY5 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Immunogen: | T cell Lymphoma cells |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Cat. #: | 151361 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology;Cell signaling and signal transduction;Immunology;Neurobiology;Stem cell biology;Tissue-specific biology |
| Application: | FACS ; IHC ; WB |
| Target: | Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45) |
| Reactivity: | Human |
| Clone: | 2B11 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | PTPRC is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Chijiwa et al. 2015. Int J Oncol. :. PMID: 25963555. Tsuneki et al. 2015. Lab Invest. :. PMID: 25961170. A hydrogel-endothelial cell implant mimics infantile hemangioma: modulation by survivin and the Hippo pathway. Establishment of patient-derived cancer xenografts in immunodeficient NOG mice. Gatter et al. 1984. Am J Clin Pathol. 82(1):33-43. PMID: 6741874. The differential diagnosis of routinely processed anaplastic tumors using monoclonal antibodies. Warnke et al. 1983. N Engl J Med. 309(21):1275-81. PMID: 6355845. Diagnosis of human lymphoma with monoclonal antileukocyte antibodies. Gatter et al. 1983. J Biol Response Mod. 2(4):369-95. PMID: 6196454. Monoclonal antibodies in diagnostic pathology: techniques and applications. |
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