CD44 is a broadly distributed receptor that binds hyaluronan. CD44 splice variants are associated with metastasis.
| Inventor | Institute |
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| John Marshall | Queen Mary University of London |
| SKU: | 151139 |
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| Product description: | CD44 is a broadly distributed receptor that binds hyaluronan. CD44 splice variants are associated with metastasis. |
| Alternate name: | CD44 Molecule; Hematopoietic Cell E- And L-Selectin Ligand; GP9 Lymphocyte Homing/Adhesion Receptor; Chondroitin Sulfate Proteoglycan 8; Extracellular Matrix Receptor III; Heparan Sulfate Proteoglycan; Phagocytic Glycoprotein; Hyaluronate Receptor; Hermes Antigen; ECMR-III; HUTCH-I; Epican; CDW44; MDU2; MDU3; MIC4; LHR; Cell Surface Glycoprotein CD44; Phagocytic Glycoprotein I; Soluble CD44; CSPG8; HCELL; PGP-1; MC56; Pgp1 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Molecular weight: | 95 kDa |
| Immunogen: | Ocular melanoma cell line (V+B2) |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Cat. #: | 151139 |
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| Provenance and Ownership: | The Anti-CD44 [P2A1] is owned by Cancer Research UK. CancerTools supplies the Anti-CD44 [P2A1] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-CD44 [P2A1] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer; Cell biology; Cell signaling and signal transduction; Immunology |
| Application: | FACS ; IHC ; IF ; IP |
| Target: | CD44 |
| Reactivity: | Human |
| Clone: | P2A1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | CD44 is a broadly distributed receptor that binds hyaluronan. CD44 splice variants are associated with metastasis. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
The Interplay of Antigen Affinity, Internalization, and Pharmacokinetics on CD44-Positive Tumor Targeting of Monoclonal Antibodies. Glatt et al. 2016. Mol Pharm. :. PMID: 27079967. Bains et al. 2002. Fertil Steril. 78(2):307-12. PMID: 12137867. Human sperm cells express CD44. Nath et al. 1999. Immunology. 98(2):213-9. PMID: 10610356. Macrophage-tumour cell interactions: identification of MUC1 on breast cancer cells as a potential counter-receptor for the macrophage-restricted receptor, sialoadhesin. |
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