CD44 is also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes.
| Inventor | Institute |
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| Margaret Goodall | University of Birmingham |
| SKU: | 153233 |
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| Product description: | The CD44 antigen is a cell-surface glycoprotein involved in cell to cell and cell-matrix interactions, cell adhesion and migration, which it achieves through its affinity for hyaluronic acid (HA) and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases. CD44 is also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. |
| Alternate name: | Cell differentiation 44; Homing cell adhesion molecule; HCAM; phagocytic glycoprotein-1; Pgp-1; Hermes antigen; lymphocyte homing receptor; ECM-III; HUTCH-1. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Cat. #: | 153233 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Cell signaling and signal transduction;Immunology |
| Application: | IHC |
| Target: | CD44 |
| Reactivity: | Human |
| Clone: | BU93 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | The CD44 antigen is a cell-surface glycoprotein involved in cell to cell and cell-matrix interactions, cell adhesion and migration, which it achieves through its affinity for hyaluronic acid (HA) and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases. CD44 is also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Leucocyte Typing IV, (1989): edited by W. Knapp, OUP, Oxford. Leucocyte Typing V, (1995): edited by S.F. Schlossman, OUP, Oxford. Leucocyte Typing VII, (2002): edited by D.Y. Mason, OUP, Oxford. |
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