CD22 which binds specifically to sialic acid with its N terminal immunoglobulin domain, is a member of the immunoglobulin superfamily due to the presence of Ig domains.
| Inventor | Institute |
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| Margaret Goodall | University of Birmingham |
| SKU: | 153221 |
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| Product description: | Cluster of differentiation 22 (CD22) is a sugar binding transmembrane protein belonging to the SIGLEC family of lectins, found on the surface of mature B cells and on some immature B cells. It acts as by preventing over activation of the immune system and the development of autoimmune diseases. CD22 which binds specifically to sialic acid with its N terminal immunoglobulin domain, is a member of the immunoglobulin superfamily due to the presence of Ig domains. CD22 functionÄËĂÂĂÂs as an inhibitory receptor for B cell receptor signalling and is also involved in the B cell trafficking to Peyer’s patches in mice. |
| Alternate name: | Cluster of differentiation-22; B cell receptor CD22 precursor; |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Tonsil derrived B cells |
| Cat. #: | 153221 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer; Cell biology; Cell signaling and signal transduction; Immunology; Stem cell biology |
| Application: | FACS ; IHC |
| Target: | CD22 |
| Reactivity: | Human |
| Clone: | BU59 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Cluster of differentiation 22 (CD22) is a sugar binding transmembrane protein belonging to the SIGLEC family of lectins, found on the surface of mature B cells and on some immature B cells. It acts as by preventing over activation of the immune system and the development of autoimmune diseases. CD22 which binds specifically to sialic acid with its N terminal immunoglobulin domain, is a member of the immunoglobulin superfamily due to the presence of Ig domains. CD22 function’s as an inhibitory receptor for B cell receptor signalling and is also involved in the B cell trafficking to Peyer’s patches in mice. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Leucocyte Typing V, (1995): edited by S.F. Schlossman, OUP, Oxford. |
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