Cluster of differentiation 21 (CD21) is a protein encoded by the CR2 gene in humans. It is involved in the complement system and binds to iC3b (an inactive derivative of C3b). B cells are known to have CR2 receptors on their surfaces allowing the complement system to act in B-cell maturation and activation. Genetic variations are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9) which is a chronic autoimmune disease with an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes.
| Inventor | Institute |
|---|---|
| Margaret Goodall | University of Birmingham |
| SKU: | 153223 |
|---|---|
| Product description: | Cluster of differentiation 21 (CD21) is a protein encoded by the CR2 gene in humans. It is involved in the complement system and binds to iC3b (an inactive derivative of C3b). B cells are known to have CR2 receptors on their surfaces allowing the complement system to act in B-cell maturation and activation. Genetic variations are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9) which is a chronic autoimmune disease with an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. |
| Alternate name: | Complement receptor type 2; CR2; complement C3d receptor, C3DR, Epstein-Barr virus receptor |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Daudi cell line (B lymphoblast) |
| Cat. #: | 153223 |
|---|---|
| Unit size: | 100 ug |
| Research Fields: | Immunology |
| Application: | IHC |
| Target: | CD21 |
| Reactivity: | Human |
| Clone: | BU80 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Cluster of differentiation 21 (CD21) is a protein encoded by the CR2 gene in humans. It is involved in the complement system and binds to iC3b (an inactive derivative of C3b). B cells are known to have CR2 receptors on their surfaces allowing the complement system to act in B-cell maturation and activation. Genetic variations are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9) which is a chronic autoimmune disease with an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. |
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| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Leucocyte Typing IV, (1989): edited by W. Knapp, OUP, Oxford. Leucocyte Typing V, (1995): edited by S.F. Schlossman, OUP, Oxford. Leucocyte Typing VI, (1998): edited by T. Kishimoto, Garland Publishing, New York. |
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