Anti-CD1c [M241] mAb
Exclusive toolM241 is useful for identification and elimination of some leukaemias.
Contributors
| Inventor | Institute |
|---|---|
| Walter Bodmer | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| SKU: | 151130 |
|---|---|
| Product description: | M241 is useful for identification and elimination of some leukaemias. |
| Alternate name: | CD1c Molecule; CD1C Antigen; C Polypeptide; CD1c Antigen; Differentiation Antigen CD1-Alpha-3; Cortical Thymocyte Antigen; CD1C; BDCA1; CD1A; CD1; R7 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 45 kDa |
| Immunogen: | MOLT 4 cell line |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Cat. #: | 151130 |
|---|---|
| Provenance and Ownership: | The Anti-CD1c [M241] mAb is owned by Cancer Research UK. CancerTools supplies the Anti-CD1c [M241] mAb under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-CD1c [M241] mAb directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer; Cell biology; Immunology |
| Application: | IHC ; IP ; RIA |
| Target: | CD1c (Human Thymus Leukaemia antigen) |
| Reactivity: | Human |
| Clone: | M241 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Cluster of Differentiation 1c (CD1c) is one of five human CD1 isoforms, a family of b2-microglobulin-associated transmembrane proteins that bind and present lipid antigens to T cells. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
MiR-381-3p Regulates the Antigen-Presenting Capability of Dendritic Cells and Represses Antituberculosis Cellular Immune Responses by Targeting CD1c. Wen et al. 2016. J Immunol. :. PMID: 27296666. Small et al. 1989. Hum Immunol. 25(3):181-93. PMID: 2670851. Characterization of B cells in severe combined immunodeficiency disease. Merle-Beral et al. 1988. Eur J Haematol. 41(3):197-203. PMID: 3263283. Phenotypic heterogeneity of B- and T-cell differentiation antigens in B-CLL. Matsumoto et al. 1986. J Immunol. 137(9):2907-12. PMID: 2428878. Fn analysis of activated C1s, a subcomponent of the first component of human complement, by monoclonal antibodies. Knowles et al. 1982. Eur J Immunol. 12(8):676-81. PMID: 6754387. A monoclonal antibody recognizing a human thymus leukemia-like antigen associated with beta 2-microglobulin. |
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Adapted from Wen Q; Zhou C; Xiong W; Su J; He J; Zhang S; Du X; Liu S; Wang J; Ma L. MiR-381-3p Regulates the Antigen-Presenting Capability of Dendritic Cells and Represses Antituberculosis Cellular Immune Responses by Targeting CD1c. J Immunol. 2016 Jul 15;197(2)
