Anti-CD195 [HEK/1/85a/7a]

Recent studies have shown CCR5 to play a role in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.

Contributors

Institute
University of Reading
SKU: 153524
Product description: CD195 or CCR5 (CC-chemokine receptor type 5) is a receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. It may play a role in the control of granulocytic lineage proliferation or differentiation, and has been shown to act as a co-receptor for HIV-1 R5 isolates. Recent studies have shown CCR5 to play a role in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.
Alternate name: Anti-CCR5, CCR5 Antibody, CD195 Antibody, C-C chemokine receptor type 5, HIV-1 fusion co-receptor
Conjugation: Unconjugated
Isotype: IgG2a kappa
Immunogen: CHO cells transfected with human CCR5
Myeloma used: Y3.AG.1.2.3
Cat. #: 153524
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Immunology; Microbiology
Application: FACS ; IF ; Fn
Target: CD195
Reactivity: Human
Clone: HEK/1/85a/7a
Host: Rat
Class: Monoclonal
Target background: CD195 or CCR5 (CC-chemokine receptor type 5) is a receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. It may play a role in the control of granulocytic lineage proliferation or differentiation, and has been shown to act as a co-receptor for HIV-1 R5 isolates. Recent studies have shown CCR5 to play a role in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Mueller et al. 2002. Blood. 99(3):785-91. PMID: 11806977.

Pathways for internalization and recycling of the chemokine receptor CCR5.

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