CD19 assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
| Inventor | Institute |
|---|---|
| Jacqueline Cordell | University of Oxford |
| SKU: | 151788 |
|---|---|
| Product description: | CD19 is a cell surface molecule expressed on B lymphocytes and follicular dendritic cells. It is expressed by most pre-B cells and by the majority of non-T-cell acute lymphocytic leukaemias and B-cell type chronic lymphocytic leukaemias. CD19 assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. |
| Alternate name: | CD19 Molecule; B-Lymphocyte Surface Antigen B4; T-Cell Surface Antigen Leu-12; Differentiation Antigen CD19; CD19 Antigen; CVID3; B4 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Immunogen: | A synthetic peptide, corresponding to the C-Terminus of CD19. |
| Myeloma used: | NS0 |
| Cat. #: | 151788 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell signaling and signal transduction;Immunology;Stem cell biology |
| Application: | IHC ; WB |
| Target: | CD19 |
| Reactivity: | Human |
| Clone: | LC-1/32/A10 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | CD19 is a cell surface molecule expressed on B lymphocytes and follicular dendritic cells. It is expressed by most pre-B cells and by the majority of non-T-cell acute lymphocytic leukaemias and B-cell type chronic lymphocytic leukaemias. CD19 assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -20° C |
| Shipping conditions: | Dry ice |
| References: |
Carter et al. 1992. Science. 256(5053):105-7. PMID: 1373518. CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. Tedder et al. 1989. J Immunol. 143(2):712-7. PMID: 2472450. Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily. |
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