| Inventor | Institute |
|---|---|
| Margaret Goodall | University of Birmingham |
| SKU: | 153231 |
|---|---|
| Product description: | The CD18 protein is the integrin beta chain beta 2. Integrins are integral cell-surface proteins composed of alpha and beta chains. A given chain may combine with multiple partners resulting in different integrins. In humans a lack of CD18 causes leukocyte adhesion deficiency, a disease defined by a lack of leukocyte extravasation from blood into tissues. The beta 2 integrins have also been found in a soluble form and these ligand binding proteins are inversely associated with disease activity in the autoimmune disease spondyloarthritis. |
| Alternate name: | Cell differentiation 18; Integrin beta-2; ITGB2 gene |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Cat. #: | 153231 |
|---|---|
| Unit size: | 100 ug |
| Research Fields: | Cell biology; Cell signaling and signal transduction; Immunology; Stem cell biology |
| Application: | IHC |
| Target: | CD18 |
| Reactivity: | Human ; Pig ; Primate |
| Clone: | BU87 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | The CD18 protein is the integrin beta chain beta 2. Integrins are integral cell-surface proteins composed of alpha and beta chains. A given chain may combine with multiple partners resulting in different integrins. In humans a lack of CD18 causes leukocyte adhesion deficiency, a disease defined by a lack of leukocyte extravasation from blood into tissues. The beta 2 integrins have also been found in a soluble form and these ligand binding proteins are inversely associated with disease activity in the autoimmune disease spondyloarthritis. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
10431789: Leucocyte Typing VI, 1998, Kishimoto_T. Garland Publishing, NY. |
|---|
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