CD11c is known to be expressed on monocytes/macrophages, granulocytes, activated B cells, in spleen and in bone marrow.
| Inventor | Institute |
|---|---|
| Jacqueline Cordell | University of Oxford |
| SKU: | 151791 |
|---|---|
| Product description: | The integrin alpha X chain protein (CD11c) belongs to the ?ĂÂ2 integrin subfamily. Integrins are cell surface receptors composed of a heterodimer containing an a and ?ĂÂ subunit. CD11c (the a subunit) combines with CD18 (the ?ĂÂ subunit) to form the leukocyte specific integrin inactivated-C3b receptor 41,2. CD11c is known to be expressed on monocytes/macrophages, granulocytes, activated B cells, in spleen and in bone marrow. |
| Alternate name: | Integrin Subunit Alpha X; Leukocyte Adhesion Glycoprotein P15;95 Alpha Chain; Complement Component 3 Receptor 4 Subunit; Leukocyte Adhesion Receptor P15;95; CD11 Antigen-Like Family Member C; CD11C |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Immunogen: | Synthetic peptide conjugated to KLH corresponding to the C terminus of human CD11C: ANGQIAPENGTQTPSPPSEK |
| Myeloma used: | NS0 |
| Cat. #: | 151791 |
|---|---|
| Unit size: | 100 ug |
| Research Fields: | Cell biology; Cell signaling and signal transduction; Immunology; Stem cell biology |
| Application: | IP ; WB |
| Target: | CD11C, Integrin, alpha X (complement component 3 receptor 4 subunit). ITGAX |
| Reactivity: | Human |
| Clone: | CD11C-100/D2 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | The integrin alpha X chain protein (CD11c) belongs to the ?ĂÂ2 integrin subfamily. Integrins are cell surface receptors composed of a heterodimer containing an a and ?ĂÂ subunit. CD11c (the a subunit) combines with CD18 (the ?ĂÂ subunit) to form the leukocyte specific integrin inactivated-C3b receptor 41,2. CD11c is known to be expressed on monocytes/macrophages, granulocytes, activated B cells, in spleen and in bone marrow. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1mg/ml |
| Storage buffer: | RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Myones BL, et al., J Clin Invest. 1988 (2):640-51. PMID: 2969921 Bilsland et al., 1994. J. Immunol. 152(9):4582-9. PMID: 7512600 Ihanus E, et al., Blood. 2007 109(2):802-10. PMID: 16985175 Ammon C et al. Immunology. 2000. 100(3):364-9. PMID: 10929059 |
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