This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes.
| Institute |
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| Netherlands Cancer Institute |
| SKU: | 154790 |
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| Product description: | ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signalling. |
| Alternate name: | ITGAL; LFA-1A |
| Conjugation: | Unconjugated |
| Molecular weight: | 126 kDa |
| Immunogen: | Immunization of BALB/c mice with cells of the T4+T8- cytotoxic T lymphocyte clone HG-38 |
| Myeloma used: | Sp2/0-Ag14 |
| Cat. #: | 154790 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology; Cell signaling and signal transduction |
| Application: | FACS ; IP |
| Target: | CD11a |
| Reactivity: | Human |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signalling. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Rousset et al. 1989. J Immunol. 143(5):1490-8. PMID: 2547869. |
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