Monoclonal antibody which binds to an epitope within exon C of CD45.
| Institute |
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| Yale University |
| SKU: | 155248 |
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| Product description: | Monoclonal antibody which binds to an epitope within exon C of CD45. Background and Research Application CD45RC, or PTPRC, is a protein tyrosine-protein phosphatase required for T cell activation through the antigen receptor. CD45 regulates Src-family kinases, integrin-mediated signal transduction pathways and can suppress JAK kinases, acting as a negative regulator of cytokine receptor signalling. Upon T cell activation, CD45RC recruits and dephosphorylates SKAP1 and FYN. Mutations of the g… |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a kappa |
| Immunogen: | P06800 |
| Immunogen Uniprot ID: | P06800 |
| Cat. #: | 155248 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Blood cancer |
| Research Fields: | Immunology |
| Target: | CD45 |
| Class: | Monoclonal |
| Target background: | Monoclonal antibody which binds to an epitope within exon C of CD45. Background and Research Application CD45RC, or PTPRC, is a protein tyrosine-protein phosphatase required for T cell activation through the antigen receptor. CD45 regulates Src-family kinases, integrin-mediated signal transduction pathways and can suppress JAK kinases, acting as a negative regulator of cytokine receptor signalling. Upon T cell activation, CD45RC recruits and dephosphorylates SKAP1 and FYN. Mutations of the … |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | Store at -20° C frozen. Avoid repeated freeze / thaw cycles |
| Shipping conditions: | Dry ice |
| References: |
Bottomly et al. 1989. Eur J Immunol. 19(4):617-23. PMID: 2567241. |
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