CCT alpha is a molecular chaperone that assists in the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
| Inventor | Institute |
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| Keith Willison | The Institute of Cancer Research |
| SKU: | 153380 |
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| Product description: | CCT alpha is a molecular chaperone that assists in the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. |
| Alternate name: | AI528772, c-cpn, CCT alpha, CCT, CCT-alpha, CCT1, Ccta, CCTalpha, D6S23E, MGC133746, p63, T complex 1, T complex protein 1 alpha subunit, T complex protein 1, T-complex homolog TCP1, T-complex protein 1 subunit alpha, T-complex protein 1 subunit alpha B, Tailless complex polypeptide 1, Tailless complex polypeptide 1A, Tailless complex polypeptide 1B, TCP 1 alpha |
| Conjugation: | Unconjugated |
| Isotype: | IgG2b |
| Molecular weight: | 60 kDa |
| Cat. #: | 153380 |
|---|---|
| Provenance and Ownership: | The Anti-CCT alpha [22245A1] is owned by Cancer Research UK. CancerTools supplies the Anti-CCT alpha [22245A1] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-CCT alpha [22245A1] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Apoptosis and autophagy; Cancer; Cell biology; Immunology |
| Application: | WB |
| Target: | CCT alpha |
| Reactivity: | Bovine ; Chicken ; Hamster ; Mouse ; Rat ; Rabbit ; Sheep |
| Clone: | 22245A1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | CCT alpha is a molecular chaperone that assists in the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Gao et al. 2013. J Biol Chem. 288(36):25760-8. PMID: 23888055. Splice isoforms of phosducin-like protein control the expression of heterotrimeric G proteins. |
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