Anti-calcium-sensing receptor [HL1499]

CaSR has been shown to be involved in Alzheimer’s Disease, asthma, and cancer

Contributors

Inventor Institute
R. Tyler Miller University of Florida Research Foundation
SKU: 158407
Product description: Calcium-sensing receptor (CaSR) is a GPCR sensing extracellular levels of calcium ions and is primarily expressed in the renal tubes of the kidney and in the parathyroid gland. Mutations have been known to cause several disorders such as familial hypocalciuris hypercalemia, autosomal dominant hypocalcemia and Type 6 Bartter syndrome. CaSR has also been shown to be involved in Alzheimer's Disease, asthma, and cancer. CaSR has been shown to interaction with filamin, which is not present in certain types of cancers, and can only activate ERK in the presence of filamin.
Alternate name: CaSR, CaR
Conjugation: Unconjugated
Isotype: IgG1 kappa
Immunogen: Synthetic peptide corresponding to amino acids 15-29 in the extracellular amino terminus of human CaSR
Cat. #: 158407
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell signaling and signal transduction;Tissue-specific biology
Application: WB ; IHC ; IP
Target: Calcium Sensing Receptor (CaSR)
Reactivity: Human ; Mouse ; Rat ; Rabbit
Host: Mouse
Class: Monoclonal
Target background: Calcium-sensing receptor (CaSR) is a GPCR sensing extracellular levels of calcium ions and is primarily expressed in the renal tubes of the kidney and in the parathyroid gland. Mutations have been known to cause several disorders such as familial hypocalciuris hypercalemia, autosomal dominant hypocalcemia and Type 6 Bartter syndrome. CaSR has also been shown to be involved in Alzheimer's Disease, asthma, and cancer. CaSR has been shown to interaction with filamin, which is not present in certain types of cancers, and can only activate ERK in the presence of filamin.
Format: Liquid
Storage conditions: -20° C
Shipping conditions: Dry ice
References:

Awata et al. 2001. J Biol Chem. 276(37):34871-9. PMID: 11390379.

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