After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.
| Inventor | Institute |
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| Walter Bodmer | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| SKU: | 153253 |
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| Product description: | C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 lambda |
| Immunogen: | Human complement component 3 |
| Myeloma used: | P3X63Ag8 |
| Cat. #: | 153253 |
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| Provenance and Ownership: | The Anti-C3 [WM1] is owned by Cancer Research UK. CancerTools supplies the Anti-C3 [WM1] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-C3 [WM1] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Biochemistry; Cell biology; Immunology; Neurobiology |
| Application: | Fn ; IP |
| Target: | Human complement component 3 |
| Reactivity: | Human |
| Clone: | WM1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. |
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| Format: | Liquid |
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| Shipping conditions: | Dry ice |
| References: |
Whitehead et al. 1981. Eur J Immunol. 11(2):140-6. PMID: 6163641. A monoclonal antibody against human complement component C3: the production of C3 by human cells in vitro. |
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