Anti-BRCA2 [MTA42]

Breast Cancer Type 2 susceptibility protein (BRCA2) is a tumour suppressor gene. BRCA2 is involved in the repair of chromosomal damage, specifically in localising Rad51 to double strand breaks. BRCA2 and BRCA1 are frequently mutated in cases of hereditary breast and ovarian cancer.

Contributors

Inventor Institute
Madalena Tarsounas Cancer Research UK, London Research Institute: Clare Hall Laboratories
Cat. #: 151571
Tool sub type: Primary antibody
Unit size: 100 ug
Cancer types: Ovarian cancer, Breast cancer
Research Fields: Cancer;Genetics
Application: ChIP ; IP ; WB
Target: BRCA2
Reactivity: Human ; Mouse
Clone: MTA42
Host: Rabbit
Class: Polyclonal
Alternate name: BRCA 2, BRCA1/BRCA2 containing complex subunit 2, Brca2, BRCA2_HUMAN, BRCC 2, BRCC2, Breast and ovarian cancer susceptibility gene early onset, Breast cancer 2 early onset, Breast Cancer 2 tumor suppressor, Breast cancer susceptibility protein BRCA2, Breast cancer type 2 susceptibility protein, BROVCA2, FACD, FAD 1, FAD, FAD1, FANCB, FANCD 1
Product description: Breast Cancer Type 2 susceptibility protein (BRCA2) is a tumour suppressor gene. BRCA2 is involved in the repair of chromosomal damage, specifically in localising Rad51 to double strand breaks. BRCA2 and BRCA1 are frequently mutated in cases of hereditary breast and ovarian cancer.
Conjugation: Unconjugated
Molecular weight: 370 kDa
Immunogen: Human BRCA2 sequence
Target background: Breast Cancer Type 2 susceptibility protein (BRCA2) is a tumour suppressor gene. BRCA2 is involved in the repair of chromosomal damage, specifically in localising Rad51 to double strand breaks. BRCA2 and BRCA1 are frequently mutated in cases of hereditary breast and ovarian cancer.
Format: Liquid
Concentration: 1.47 mg/ml
Storage buffer: PBS, 0.1% NaN3
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Zhang et al. 2012. Clin Cancer Res. 18(21):5961-71. PMID: 22977194.

FoxM1 inhibition sensitizes resistant glioblastoma cells to temozolomide by downregulating the expression of DNA-repair gene Rad51.

Badie et al. 2010. Nat Struct Mol Biol. 17(12):1461-9. PMID: 21076401.

BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping.

Images

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MTA42 is raised against C-terminus of BRCA2. HeLa cells contain full length BRCA2 whereas Capan-1 cells have a BRCA2 C-terminal truncation.

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