Monoclonal antibody which detects connexin 32, linked to Charcot-Marie-Tooth disease.
| Inventor | Institute |
|---|---|
| David Becker | University College London (UCL) |
| Cat. #: | 151524 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction;Neurobiology |
| Application: | IHC ; IF ; WB |
| Target: | Connexin 32 (Cx32 or ?1) |
| Reactivity: | Chicken ; Human ; Mouse ; Rat |
| Clone: | 2A |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Monoclonal antibody which detects connexin 32, linked to Charcot-Marie-Tooth disease. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Molecular weight: | 46 kDa |
| Immunogen: | The peptide, LEGHGDPLHLEE, was coupled at the C-terminal end to bovine thyroglobulin at a final molar ratio peptide:thyroglobulin of 4060:1. |
| Immunogen Uniprot ID: | P08034 |
| Myeloma used: | P3X63Ag8.653 |
| Target background: | Connexins are a large family of proteins which form gap junctions. Gap junctions are cell membrane structures that facilitate direct cell-cell communication. Gap junctions are essential for various physiological processes, including coordinated depolarization of cardiac muscle, proper embryonic development, and the conducted response in microvasculature. Gap junction communication has been implicated in the patterning and development of vertebrate embryos. Individual connexins show complex sp… |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | Store at -20° C frozen. Avoid repeated freeze / thaw cycles |
| Shipping conditions: | Dry ice |
| References: |
Wright et al. 2001. Reproduction. 121(1):77-88. PMID: 11226030. Stage-specific and differential expression of gap junctions in the mouse ovary: connexin-specific roles in follicular regulation. |
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