The BCR gene is involved in the 9:22 translocation that generates the Philadelphia chromosome both in chronic myeloid leukemia (CML) and in a proportion of cases of acute lymphocytic leukemia (ALL). A 5′ bcr sequence becomes fused to an abl sequence (including tyrosine kinase domain sequences) from chromosome 9 and results in the production of a chimaeric BCR-ABL protein with enhanced kinase activity. These antibodies may be useful for studies of the oncogene and have potential diagnostic and prognostic applications.
| Institute |
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| Queen Mary University of London |
| SKU: | 151054 |
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| Product description: | The BCR gene is involved in the 9:22 translocation that generates the Philadelphia chromosome both in chronic myeloid leukemia (CML) and in a proportion of cases of acute lymphocytic leukemia (ALL). A 5′ bcr sequence becomes fused to an abl sequence (including tyrosine kinase domain sequences) from chromosome 9 and results in the production of a chimaeric BCR-ABL protein with enhanced kinase activity. These antibodies may be useful for studies of the oncogene and have potential diagnostic and prognostic applications. |
| Alternate name: | Cyclin A2; Cyclin-A; CCN1; CCNA2 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | BCR-ABL peptide |
| Myeloma used: | P3X63Ag8.653 |
| Cat. #: | 151054 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Blood cancer |
| Research Fields: | Cancer;Cell signaling and signal transduction;Genetics |
| Application: | IHC ; IF ; RIA |
| Target: | BCRABL |
| Reactivity: | Human |
| Clone: | 4C12 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | The BCR gene is involved in the 9:22 translocation that generates the Philadelphia chromosome both in chronic myeloid leukemia (CML) and in a proportion of cases of acute lymphocytic leukemia (ALL). A 5′ bcr sequence becomes fused to an abl sequence (including tyrosine kinase domain sequences) from chromosome 9 and results in the production of a chimaeric BCR-ABL protein with enhanced kinase activity. These antibodies may be useful for studies of the oncogene and have potential diagnostic and prognostic applications. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Dhut et al. 1990. Leukemia. 4(11):745-50. PMID: 2232885. BCR-ABL and BCR proteins: biochemical characterization and localization. Dhut et al. 1988. Oncogene. 3(5):561-6. PMID: 3078961. Identification of two normal bcr gene products in the cytoplasm. Walker et al. 1987. Nature. 329(6142):851-3. PMID: 3478595. Novel chimaeric protein expressed in Philadelphia positive acute lymphoblastic leukaemia. |
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