Anti-BCL11A [BCL11A/123]

The BCL11A/123 antibody specifically recognises the extra long form of the protein and not the long or short forms of BCL11A. The BCL11A/123 antibody is not cross reactive with the long form of the BCL11B protein that shares significant sequence identity with the immunogen.

Contributors

Inventor Institute
Alison Banham University of Oxford
SKU: 151750
Product description: The BCL11A/123 antibody specifically recognises the extra long form of the protein and not the long or short forms of BCL11A. The BCL11A/123 antibody is not cross reactive with the long form of the BCL11B protein that shares significant sequence identity with the immunogen.
Conjugation: Unconjugated
Isotype: IgG1
Molecular weight: Predicted 91 kDa
Immunogen: C-terminus of extra long isoform of BCL11A, BCL11AXL (aa 637-835)
Myeloma used: P3/NS1/1-Ag4.1
Cat. #: 151750
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer; Genetics; Neurobiology
Application: IHC ; IP ; WB
Target: BCL11A (EVI9, CTIP1)
Reactivity: Human ; Rat
Clone: BCL11A/123
Host: Mouse
Class: Monoclonal
Target background: BCL11A is a KrĂźppel zinc-finger transcription factor that was identified originally from a chromosome translocation in aggressive B-cell chronic lymphocytic leukaemia. The gene may function as both an oncogene and a tumour suppressor. Alternative splicing generates multiple isoforms, the BCL11AXL being the largest and most abundant transcript. The protein is differentially expressed during B-cell development and is strongly expressed in plasmacytoid dendritic cells.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Chetaille et al. 2009. Blood. 113(12):2765-3775. PMID: 19096012.

Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome.

Marafioti et al. 2008. Blood. 111(7):3778-92. PMID: 18218851.

Novel markers of normal and neoplastic human plasmacytoid dendritic cells.

Weniger et al. 2006. Leukemia. 20(10):1880-2. PMID: 16871282.

Pulford et al. 2006. Leukemia. 20(8):1439-41. PMID: 16710303.

Gains of the proto-oncogene BCL11A and nuclear accumulation of BCL11A(XL) protein are frequent in primary mediastinal B-cell lymphoma.

The BCL11AXL transcription factor: its distribution in normal and malignant tissues and use as a marker for plasmacytoid dendritic cells.

Liu et al. 2006. Mol Cancer. 5:18. PMID: 16704730.

Fn studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells.

Images

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BCL11AXL (BCL123a) expression in tonsil BCL11AXL is present in B cells (brown) in germinal centres and mantle zones.

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