BCL-10 is an apoptotic regulatory molecule, of approximately 31 kDa
| Inventor | Institute |
|---|---|
| Ming-Qing Du | University College London (UCL) |
| SKU: | 151821 |
|---|---|
| Product description: | BCL-10 is an apoptotic regulatory molecule, of approximately 31 kDa. It was identified through its direct involvement in t(1:14) (p22;q32) of mucosa-associated lymphoid tissue (MALT) lymphoma. In B-cell follicles, BCL10 has been shown to be expressed abundantly in the germinal center B cells, moderately in the marginal zone, but only weakly in mantle zone B cells. This differential expression is an indicator of its importance in maturation and malignant transformation of human B-cells. BCL-10 contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Immunogen: | Full-length recombinant BCL-10 protein |
| Myeloma used: | NS0 |
| Cat. #: | 151821 |
|---|---|
| Provenance and Ownership: | The Anti-BCL10 151 is owned by Cancer Research UK. CancerTools supplies the Anti-BCL10 151 under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-BCL10 151 directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Apoptosis and autophagy; Cancer; Cell signaling and signal transduction; Metabolism |
| Application: | ELISA ; IHC ; WB |
| Target: | Bcl10 |
| Reactivity: | Human |
| Clone: | 151 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | BCL-10 is an apoptotic regulatory molecule, of approximately 31 kDa. It was identified through its direct involvement in t(1:14) (p22;q32) of mucosa-associated lymphoid tissue (MALT) lymphoma. In B-cell follicles, BCL10 has been shown to be expressed abundantly in the germinal center B cells, moderately in the marginal zone, but only weakly in mantle zone B cells. This differential expression is an indicator of its importance in maturation and malignant transformation of human B-cells. BCL-10 contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Shen et al. 2003. Blood. 102(4):1553-4. PMID: 12900354. Aberrant BCL10 nuclear expression in nasal NK/T-cell lymphoma. Ye et al. 2000. Am J Pathol. 157(4):1147-54. PMID: 11021819. BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma. Du et al. 2000. Blood. 95(12):3885-90. PMID: 10845924. BCL10 gene mutation in lymphoma. |
|---|
| Cat. # | Tool Name | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 151026 | Anti-FCGR1 [10.1] mAb |
Key Info
Anti-FCGR1 [10.1] mAb
|
View Tool | |||||||||||||||||||
| 151015 | Anti-CyclinA [E70.1] |
Key Info
Anti-CyclinA [E70.1]
|
View Tool | |||||||||||||||||||
| 151023 | Anti-IL12 [1-1D5] |
Key Info
Anti-IL12 [1-1D5]
|
View Tool | |||||||||||||||||||
| 151038 | Anti-Cytochrome P450 4A2, 4A3 [Clo4] |
Key Info
Anti-Cytochrome P450 4A2, 4A3 [Clo4]
|
View Tool | |||||||||||||||||||
| 151039 | Anti-Integrin aVb3 [23C6] |
Key Info
Anti-Integrin aVb3 [23C6]
|
View Tool | |||||||||||||||||||
Please note we may take up to three days to respond to your enquiry.
CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.