Specifically, Apc11 acts as an E3 enzyme and is responsible for recruiting E2s to the APC and for mediating the subsequent transfer of ubiquitin to APC substrates in vivo.
| Inventor | Institute |
|---|---|
| Julian Gannon | Cancer Research UK, London Research Institute: Clare Hall Laboratories |
| SKU: | 151535 |
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| Product description: | APC11 is the catalytic subunit of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. Specifically, Apc11 acts as an E3 enzyme and is responsible for recruiting E2s to the APC and for mediating the subsequent transfer of ubiquitin to APC substrates in vivo. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Peptide spanning carboxy region of APC11. |
| Myeloma used: | Sp2/0-Ag14 |
| Cat. #: | 151535 |
|---|---|
| Provenance and Ownership: | The Anti-APC11 [AX2.1] is owned by Cancer Research UK. CancerTools supplies the Anti-APC11 [AX2.1] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-APC11 [AX2.1] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Biochemistry; Cell biology |
| Application: | ELISA ; WB |
| Target: | Anaphase Promoting Complex (APC) 11 |
| Reactivity: | Human ; Xenopus laevis |
| Clone: | AX2.1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | APC11 is the catalytic subunit of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. Specifically, Apc11 acts as an E3 enzyme and is responsible for recruiting E2s to the APC and for mediating the subsequent transfer of ubiquitin to APC substrates in vivo. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
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