Anti-APC [Ali 12-28]

Ali 12-28 may be used for the detection of APC expression and APC mutations.

Contributors

Inventor Institute
Walter Bodmer Cancer Research UK, London Research Institute: Lincoln's Inn Fields
SKU: 151073
Product description: Ali 12-28 may be used for the detection of APC expression and APC mutations.
Conjugation: Unconjugated
Isotype: IgG1
Molecular weight: 310 kDa
Immunogen: N-terminal APC-MBP fusion protein
Myeloma used: Sp2/0-Ag14
Cat. #: 151073
Provenance and Ownership: The Anti-APC [Ali 12-28] is owned by Cancer Research UK. CancerTools supplies the Anti-APC [Ali 12-28] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-APC [Ali 12-28] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Tool sub type: Primary antibody
Unit size: 100 ug
Cancer types: Colorectal cancer; Other
Research Fields: Cancer; Cell biology; Cell signaling and signal transduction; Genetics; Neurobiology; Stem cell biology; Tissue-specific biology
Application: WB ; ELISA ; IHC ; IF ; IP ; WB
Target: Adenomatous Polyposis Coli (APC)
Reactivity: Human
Clone: Ali 12-28
Host: Mouse
Class: Monoclonal
Target background: The adenomatous polyposis coli (APC) tumour suppressor gene is mutated (often by deletion of the C-terminal portion of APC) in the inherited disease, familial adenomatous polyposis (FAP), and in over 80% of colorectal cancers.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Hadjihannas et al. 2012. EMBO Rep. 13(4):347-54. PMID: 22322943.

Cell cycle control of Wnt/?-catenin signalling by conductin/axin2 through CDC20.

Valvezan et al. 2012. J Biol Chem. 287(6):3823-32. PMID: 22184111.

Tanneberger et al. 2011. J Biol Chem. 286(22):19204-14. PMID: 21498506.

Structural and Fn characterization of the Wnt inhibitor APC membrane recruitment 1 (Amer1).

Arnold et al. 2009. EMBO J. 28(5):500-12. PMID: 19131971.

The Axin1 scaffold protein promotes formation of a…

Images

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From Boehlke et al. PLoS ONE 8(9)

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