AP-2 is a family of developmentally regulated transcription factors which also play a role in breast cancer and melanoma. AP-2?Ÿ may be important in cardiac and kidney development. The AP-2 transcription factors form the OB2 complex that has been shown to up-regulate c-erb-B2 transcription.
| Inventor | Institute |
|---|---|
| Helen Hurst | Queen Mary University of London |
| Cat. #: | 151255 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Genetics;Tissue-specific biology |
| Application: | IHC ; IP ; WB |
| Target: | Activating Protein 2 (AP-2) gamma |
| Reactivity: | Human ; Mouse |
| Clone: | AP2g 6E4/4 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | AP-2 is a family of developmentally regulated transcription factors which also play a role in breast cancer and melanoma. AP-2?ĂÂ may be important in cardiac and kidney development. The AP-2 transcription factors form the OB2 complex that has been shown to up-regulate c-erb-B2 transcription. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 50 kDa |
| Immunogen: | Bacterially produced AP-2a/AP-2g fusion protein (c-terminal half of AP-2 gamma) |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | AP-2 is a family of developmentally regulated transcription factors which also play a role in breast cancer and melanoma. AP-2? may be important in cardiac and kidney development. The AP-2 transcription factors form the OB2 complex that has been shown to up-regulate c-erb-B2 transcription. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Gee et al. 2009. J Pathol. 217(1):32-41. PMID: 18825690. Overexpression of TFAP2C in invasive breast cancer correlates with a poorer response to anti-hormone therapy and reduced patient survival. Eloranta et al. 2002. J Biol Chem. 277(34):30798-804. PMID: 12072434. Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo. |
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