Anti-Alkaline phosphatase [AAP1]

Alkaline phosphatases are phosphodiesterases which remove phosphate groups from the 5′ end of DNA, RNA and proteins at high pH. The placental-specific isozyme of Alkaline Phosphatase (PLAP) is found in trophoblast cells of normal human mature placenta, seminomas of testis and ovarian carcinomas. Detection of alkaline phosphatase in serum is a marker for ovarian and testicular cancer.

Contributors

Inventor Institute
Walter Bodmer Cancer Research UK, London Research Institute: Lincoln's Inn Fields
SKU: 151071
Product description: Alkaline phosphatases are phosphodiesterases which remove phosphate groups from the 5′ end of DNA, RNA and proteins at high pH. The placental-specific isozyme of Alkaline Phosphatase (PLAP) is found in trophoblast cells of normal human mature placenta, seminomas of testis and ovarian carcinomas. Detection of alkaline phosphatase in serum is a marker for ovarian and testicular cancer.
Conjugation: Unconjugated
Isotype: IgG2a
Immunogen: D98/AH-2 (HeLa) cells, which produce human intestinal alkaline phosphatase ectopically
Myeloma used: P3X63Ag8
Cat. #: 151071
Provenance and Ownership: The Anti-Alkaline phosphatase [AAP1] is owned by Cancer Research UK. CancerTools supplies the Anti-Alkaline phosphatase [AAP1] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-Alkaline phosphatase [AAP1] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer; Cell biology
Application: WB ; ELISA
Target: Alkaline phosphatase
Reactivity: Human
Clone: AAP1
Host: Mouse
Class: Monoclonal
Target background: Alkaline phosphatases are phosphodiesterases which remove phosphate groups from the 5′ end of DNA, RNA and proteins at high pH. The placental-specific isozyme of Alkaline Phosphatase (PLAP) is found in trophoblast cells of normal human mature placenta, seminomas of testis and ovarian carcinomas. Detection of alkaline phosphatase in serum is a marker for ovarian and testicular cancer.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Brock et al. 1985. Lancet. 1(8439):1175-8. PMID: 2860384.

Prospective prenatal diagnosis of cystic fibrosis.

Arklie et al. 1981. Tissue Antigens. 17(3):303-12. PMID: 7314066.

A monoclonal antibody to intestinal alkaline phosphatase made against D98/AH-2 (HeLa) cells.

Images

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Arklie et al. 1981. Tissue Antigens. 17(3)

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