Anti-Acetyl SMC3 [DP3.1]

SMC3 is a central component of cohesin, a complex required for chromosome cohesion during the cell cycle.

Contributors

Inventor Institute
Julian Gannon Cancer Research UK, London Research Institute: Clare Hall Laboratories
SKU: 153177
Product description: SMC3 is a central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement.SMC3 is unacetylated in egg extracts. It is only acetylated in chromatin preparations from extracts where the DNA has replicated.
Conjugation: Unconjugated
Molecular weight: 141 kDa
Immunogen: Synthetic peptide – EEVSLRRVIGAKacetyl Kacetyl DQYFLDKK
Cat. #: 153177
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Cell biology;Genetics
Application: WB
Target: Acetyl SMC3
Reactivity: Xenopus laevis
Clone: DP3.1
Host: Mouse
Class: Monoclonal
Target background: SMC3 is a central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement.SMC3 is unacetylated in egg extracts. It is only acetylated in chromatin preparations from extracts where the DNA has replicated.
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice

Images

View Gallery
Figure. Immoblots using Anti-Acetyl SMC3 [DP3.1]; Anti-Acetyl SMC3 [DP4.1] and Anti-SMC3 [DJ5.2.3]. DJ5.2.3 immunoblots all forms of SMC3 while DP3.1 and DP4.1 immunoblots only the Acetyl SMC3.

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