Phosphatidylinositol-4-phosphate 5-kinase inhibitor PIP5K Small Molecule (Tool Compound)

A selective inhibitor of phosphatidylinositol-4-phosphate 5-kinase (PIP5K) which demonstrates anti-cancer activity.

Contributors

Inventor Institute
Martin Swarbrick Cancer Research Technology AstraZeneca Metabolism Alliance Team
Cat. #: 160406
Tool sub type: Inhibitor
Research Fields: Cancer
Purpose: Inhibitor
Alternate name: Synonyms for Phosphatidylinositol-4-phosphate 5-kinase: PIKFYVE, Phosphoinositide Kinase, FYVE Finger Containing Phosphatidylinositol-3-Phosphate/Phosphatidylinositol 5-Kinase Type III, Phosphatidylinositol 3-Phosphate 5-Kinase Type III, Type III PIP Kinase, PIPkin-III, PIP5K3, FYVE Finger-Containing Phosphoinositide Kinase 4, 1-Phosphatidylinositol-3-Phosphate 5-Kinase, Phosphatidylinositol 3-Phosphate 5-Kinase, Zinc Finger FYVE Domain Containing, Epididymis Luminal Protein 37, FYVE Domain Containing 29, KIAA981, ZFYVE29, PIKfyve, HEL37, PIP5K, FAB1, CFD
Additional notes: Relevant Indications: PI3K, PLC, Wnt, Fc-receptor, BAF Negative Control Available: No The compounds are made up to 12mM stock concentration in DMSO. The final concentration of DMSO when treating cells should be less than 1%.
Selectivity: PI4KCA IC50: 20.9 ÂľM PI4KCB IC50: 5.99 ÂľM PI3KÎą IC50: 34.6 ÂľM
Primary target: Phosphatidylinositol-4-phosphate 5-kinase (PIP5K)
Shipping conditions: Dry Ice
Solubility: 15 ľM (Aqueous)
References:

Andrews et al. 2014. Eur. J. Cancer. 50(6):91

Related Tools for Small molecules

Cat. # Tool Name
151839 Antitumoral Phortress Small Molecule (Tool Compound) Key Info View Tool
151843 AKR1C3 inhibitor CRT0036521 Small Molecule (Tool Compound) Key Info View Tool
151879 AKR1C3 inhibitor CRT0083914 Small Molecule (Tool Compound) Key Info View Tool
151889 DNA-PK inhibitor NU7441 Small Molecule (Tool Compound) Key Info View Tool
153191 CDK inhibitor BS-194 Small Molecule (Tool Compound) Key Info View Tool

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.