Penta-PT conjugate small molecule (tool compound)

Adapted from WO2014/195881 Bordetella pertussis causes whooping cough, a highly contagious disease involving the respiratory tract, which is especially serious for infants and young children. Despite widespread immunization, in recent years the number of pertussis incidences has increased. The limited efficacy of currently used pertussis vaccines results from the fact that their components do not […]

Contributors

Inventor Institute
Czeslaw Lugowski ; Tomasz Niedziela ; Sabina Koj Polish Center for Technology Development/Polski Ośrodek Rozwoju Technologii (PORT)
Cat. #: 160588
Research Fields: Drug development;Immunology
Product description: Adapted from WO2014/195881 Bordetella pertussis causes whooping cough, a highly contagious disease involving the respiratory tract, which is especially serious for infants and young children. Despite widespread immunization, in recent years the number of pertussis incidences has increased. The limited efficacy of currently used pertussis vaccines results from the fact that their components do not induce a complete immune response. Unlike tetanus and diphtheria diseases where all symptoms are …
Additional notes: Adapted from WO2014/195881 Glycoconjugate of the distal pentasaccharide obtained by deamination of LOS (from Bordetella pertussis) conjugated to a pertussis toxin. The pentasaccharide part of the conjugate is a fragment isolated from the LOS of B. pertussis 186 and it comprises a distal trisaccharide, a heptose and an anhydromannose. It has been shown that pentasaccharide-TTd conjugate induced antibodies which were able to bind to B. pertussis in immunofluorescence assays (FACS). Moreover, us…
Selectivity: This pentasaccharide-PT glycoconjugate is not capable of binding to fetuin in ELISA test.
References:

WO2014195881 – BORDETELLA PERTUSSIS LOS-DERIVED OLIGOSACCHARIDE WITH PERTUSSIS TOXIN GLYCOCONJUGATE AND ITS APPLICATION IN THE PROPHYLAXIS AND TREATMENT OF INFECTIONS CAUSED BY BORDETELLA PERTUSSIS

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