Cat. #157976
Heat shock protein 70 (HSP70) inhibitor JG-98
Cat. #: 157976
Sub-type: Inhibitor
Availability: Please enquire for quantities and pricing
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Jason Gestwicki
Institute: University of Michigan
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: Heat shock protein 70 (HSP70) inhibitor JG-98
- Research fields: Cancer
- Tool sub type: Inhibitor
- Primary target: Heat shock protein 70 (HSP70)
- Description: The benzothiazole rhodacyanines, MKT-077 analogue, JG-98 was designed as a small molecule with greater stability and potency to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones. Inhibiting Hsp70 chaperones induce apoptosis in breast cancer cell lines and xenograft model. This inhibitor would be useful in the study of Hsp70 chaperones and oncology research.
- Purpose: Inhibitor
Handling
- Shipping conditions: Dry Ice
Target Details
- Primary target: Heat shock protein 70 (HSP70)
Related Tools
- Related tools: Heat shock protein 70 (HSP70) inhibitor JG-231 ; Heat shock protein 70 (HSP70) inhibitor JG-345
References
- Shao et al. 2020. Bioorg Med Chem Lett. 30(5):126954. PMID: 31952963.
- Taguwa et al. 2019. Cell Rep. 26(4):906-920.e3. PMID: 30673613.
- Rinaldi et al. 2018. ACS Chem Biol. 13(11):3142-3152. PMID: 30372610.
- Shao et al. 2018. J Med Chem. 61(14):6163-6177. PMID: 29953808.
- Young et al. 2016. Cell Chem Biol. 23(8):992-1001. PMID: 27499529.
- Li et al. 2013. ACS Med Chem Lett. 4(11):. PMID: 24312699.
- Rousaki et al. 2011. J Mol Biol. 411(3):614-32. PMID: 21708173.
