CS-5c Bcr-Abl and Btk small molecule kinase inhibitors

This compound inhibits in nanomolar scale for Bcr-Abl (40 nM) and sub-micromolar scale for Btk kinases

Contributors

Inventor Institute
Cristian Salas Pontificia Universidad Catolica de Chile
Cat. #: 160518
Tool sub type: Inhibitor
Research Fields: Cancer;Drug development;Other
Purpose: Inhibitor
Product description: This compound inhibits in nanomolar scale for Bcr-Abl (40 nM) and sub-micromolar scale for Btk kinases (0,58 <U+00B5>M), both are related to the genesis and progression of myeloid and lymphoid leukaemia, respectively
Molecular weight: 472.5605
Primary target: Bcr-Abl and Btk kinases
Storage conditions: Away from UV light
Shipping conditions: Dry Ice
Solubility: DMSO
References:

Bertrand et al. 2020. Bioorg Chem. 94:103361. PMID: 31699386.

Images

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1. CS-5d (9-(Cyclopropylmethyl)-N6-(3;4-difluorophenyl)-N2-(4-(4-methylpiperazin-1-yl)phenyl)-9H-purine-2;6-diamine) 2. CS-5c (9-(Cyclopropylmethyl)-N6-(3-fluorophenyl)-N2-(4-(4-methylpiperazin-1-yl)phenyl)-9H-purine-2;6-diamine)

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