TsixTAD-Inv mouse
Contributors
| Inventor | Institute |
|---|---|
| Edith HEARD; Rafael GALUPA; Fatima EL MARJOU; Colin JOUHANNEAU | Institut Curie |
| SKU: | 162171 |
|---|---|
| Product description: | This line was generated in the context of studying the relationship between chromosome organisation and gene expression at the X-inactivation centre, the regulatory locus that triggers X-chromosome inactivation. It can be used as an example of a structural variant (deletion) within the X chromosome. |
| Official nomenclature: | B6D2Fn-Tsix-TADem1Heard/Curie |
| CRISPR: | Yes |
| Cat. #: | 162171 |
|---|---|
| Research Fields: | Genetics |
| Zygosity: | Homozygous |
| Strain: | B6D2F1 |
| Primary citation: | Rafael Galupa et. al. 2022. Development. May 1;149(9):dev200568. PMID: 35502750. |
| Shipping conditions: | Sperm / dry ice |
|---|
| References: |
Rafael Galupa et. al. 2022. Development. May 1 149(9):dev200568. PMID: 35502750. |
|---|
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TsixTAD-Inv mouse
(Up) Targeting strategy for inverting the ∼245 kb region comprising most of the Tsix-TAD, except Tsix and its known regulator Xite, and leaving the boundaries intact.
(Down) Crosses used for the analysis of RNA allelic ratios in female hybrid embryos inheriting the Mus musculus domesticus allele maternally (red).
RNA allelic ratios for the X-linked gene Atp7a (Middle) and Xist (Right). Each black dot corresponds to a single female embryo. Box-and-whisker plots indicate median, interquartile range and min/max values, respectively, with blue and red plots indicating paternally or maternally inherited alleles, respectively.
