A mouse model with epidermal FgfR 2b expression knocked out. The mouse lives a normal life span but has altered hair morphology.
| Inventor | Institute |
|---|---|
| Clive Dickson | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| SKU: | 151561 |
|---|---|
| Product description: | A mouse model with epidermal FgfR 2b expression knocked out. The mouse lives a normal life span but has altered hair morphology. It has a tendency to develop skin papillomas spontaneously and development of these can be accelerated greatly by use of a carcinogen. |
| Conditional: | Yes |
| Conditional description: | Fgfr2bflox/flox mouse crossed with K5-Cre mouse (tissue-specific Cre expression in skin) giving tissue-specific knockout of FGFR2 IIIb isoform in skin. |
| Genetic background: | Homozygous Fgfr2bflox/flox mice, carrying a loxP flanked IIIb exon of FGFR2, were crossed with male heterozygous K5-Cre mice, carrying Cre recombinase transgene under control of the Keratin-5 promoter. Mice were maintained on a mixed 129/C57BL6 background. |
| Production details: | Homozygous Fgfr2bflox/flox mice, carrying a loxP flanked IIIb exon of FGFR2, were crossed with male heterozygous K5-Cre mice, carrying Cre recombinase transgene under control of the Keratin-5 promoter. Mice were maintained on a mixed 129/C57BL6 background. |
| Additional notes: | The K5-R2b-null mouse is an ideal tool in the study of the tumour suppressive role of the FGFR2 IIIb isoform in skin tumourigenesis.Skin tumours develop in K5-R2b-null mice following two-step carcinogen treatment with DMBA and TPA. |
| Cat. #: | 151561 |
|---|---|
| Cancer types: | Gastric cancer |
| Research Fields: | Cancer; Cell signaling and signal transduction; Genetics; Immunology |
| Target: | Fibroblast growth factor receptor 2 isoform IIIb (FGFR2IIIb) |
| Model: | Knock-Out |
| Phenotype: | Skin abnormalities, Tumourigenesis |
| Shipping conditions: | Embryo/Spermatoza- Dry Ice |
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