Cat. #151561
K5R2b Null Mouse
Cat. #: 151561
Sub-type: Mouse
Availability: 6-8 weeks
Model: Knock-Out
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Clive Dickson
Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: K5R2b Null Mouse
- Cancer: Digestive / Gastrointestinal cancer
- Cancers detailed: Gastric
- Research fields: Cancer;Cell signaling and signal transduction;Genetics;Immunology
- Tool sub type: Mouse
- Model: Knock-Out
- Conditional: Yes
- Conditional description: Fgfr2bflox/flox mouse crossed with K5-Cre mouse (tissue-specific Cre expression in skin) giving tissue-specific knockout of FGFR2 IIIb isoform in skin.
- Description: A mouse model with epidermal FgfR 2b expression knocked out. The mouse lives a normal life span but has altered hair morphology. It has a tendency to develop skin papillomas spontaneously and development of these can be accelerated greatly by use of a carcinogen.
- Application: The K5-R2b-null mouse is an ideal tool in the study of the tumour suppressive role of the FGFR2 IIIb isoform in skin tumourigenesis.Skin tumours develop in K5-R2b-null mice following two-step carcinogen treatment with DMBA and TPA.
- Genetic background: Homozygous Fgfr2bflox/flox mice, carrying a loxP flanked IIIb exon of FGFR2, were crossed with male heterozygous K5-Cre mice, carrying Cre recombinase transgene under control of the Keratin-5 promoter. Mice were maintained on a mixed 129/C57BL6 background.
- Phenotype: Skin abnormalities, Tumourigenesis
- Production details: Homozygous Fgfr2bflox/flox mice, carrying a loxP flanked IIIb exon of FGFR2, were crossed with male heterozygous K5-Cre mice, carrying Cre recombinase transgene under control of the Keratin-5 promoter. Mice were maintained on a mixed 129/C57BL6 background.
- Additional notes: The K5-R2b-null mouse is an ideal tool in the study of the tumour suppressive role of the FGFR2 IIIb isoform in skin tumourigenesis.Skin tumours develop in K5-R2b-null mice following two-step carcinogen treatment with DMBA and TPA.
Handling
- Shipping conditions: Embryo/Spermatoza- Dry Ice
Target Details
- Target: Fibroblast growth factor receptor 2 isoform IIIb (FGFR2IIIb)
Application Details
- Application: The K5-R2b-null mouse is an ideal tool in the study of the tumour suppressive role of the FGFR2 IIIb isoform in skin tumourigenesis.Skin tumours develop in K5-R2b-null mice following two-step carcinogen treatment with DMBA and TPA.
