AEG-1DeltaMAC mouse

Mouse model with conditional AEG-1 knockout in myeloid cells

Contributors

Inventor Institute
Devanand Sarkar Virginia Commonwealth University
Cat. #: 154269
Research Fields: Cancer;Cell signaling and signal transduction;Genetics;Immunology
Target: Astrocyte Elevated Gene-1
disease: Hepatocellular Carcinogenesis
Model: Conditional KO
Zygosity: unknown
Strain: C57BL/6
Phenotype: Hepatocellular Carcinogenesis
Product description: Mouse model with conditional AEG-1 knockout in myeloid cells
Conditional: Yes
Conditional description: Conditional AEG-1ΔMAC knockout after single i.p. injection of 10µg/gm body weight of N-nitrosodiethylamine (DEN) given at 14 days of age followed by 0.05% phenobarbital daily in drinking water.
Genetic background: Floxed AEG-1 mice (AEG-1fl/fl) in C57BL/6 background were crossed with LysM/Cre (B6.129P2-Lyz2tm1(cre)lfo/J
Production details: Floxed AEG-1 mice (AEG-1fl/fl) in C57BL/6 background were crossed with LysM/Cre (B6.129P2-Lyz2tm1(cre)lfo/J
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

Robertson et al. 2018. Cancer Res. 78(22):6436-6446. PMID: 30181179.

Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis.

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