VCaP 14 [ENZA D] CRPC Cell line

vCaP ENZ was created through ADT and Enzalutamide to be used as a model for CRPC

Contributors

Inventor Institute
Wytske van Weerden Erasmus University Medical Centre
Cat. #: 161963
Research Fields: Cancer
Organism: Human
Tissue: Prostate
Model: Tumour Cell Line
Primary citation: Moll JM et al. 2022. Front. Oncol. Jun 13,12:877613. PMID: 35769712
Product description: CRPC VCaP cell lines (15 sublines made resistant to common antiandrogens through long-term passaging) – Enzalutamide D. VCaP Enzalutamide cells were generated by long-term culturing of VCaP cells in androgen depleted media with Enzalutamide, an AR antagonist. These cell lines can be used to study the role of AR signalling and mechanisms of resistance to androgen deprivation therapy and AR targeting agents in CRPC. This cell line is subclone D.
Receptors of note: Androgen receptor
Parental cell line: VCaP
Model description: CRPC model
disease: Cancer
Storage conditions: liquid N2
Growth medium: RPMI1640 + 10% DCC-FCS + 1 uM ENZ
References:

Moll JM et al. 2022. Front. Oncol. Jun 13,12:877613. PMID: 35769726

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