OV-1369(R2) cell line

Relapse-derived HGSOC ascites cell line paired with TOV-1369TR for same-patient treatment-evolution studies.

Contributors

Inventor Institute
Anne-Marie Mes-Masson and Diane Provencher Centre Hospitalier de L’université de Montréal
SKU: 161769
Product description: Epithelial ovarian cancer cell lines spontaneously derived from ascites at specific time points at diagnosis and relapse. Post-treatment for breast cancer 2 years before
Alternate name: OV-1369(R2)
Gender: Female
CRISPR: No
Production details: Patient ascites were centrifuged and seeded in 100mm plate with OSE medium and maintained for 40 days with weekly media replacement.
Additional notes: Patient was diagnosed with breast cancer 18 months before ovarian cancer diagnosis. After surgical resection for breast cancer and 14 months before ovarian cancer diagnosis, patient had docetaxel treatment. Patient was also entrolled in a clinical trial obtaining doxorubicin, docetaxel with or without cyclophosphamide and received radiotherapy 12 months before ovarian cancer diagnosis. After ovarian cancer diagnosis, patient received paclitaxel and carboplatin for 5 months and was initially r…
Receptors of note: No
Related tools: 161768
Cat. #: 161769
Cancer types: Ovarian cancer
Research Fields: Cancer
Organism: Human
Tissue: Derived from ascites of patient diagnosed with high-grade serous ovarian cancer at specific time points at diagnosis and relapse
Gender: Female
Morphology: Expresssion of tumor suppressor p53 present. Strong HER2 expression detected in protein extracts and observed in solid tissues by IHC. Spheroid formation: aggregate
Growth properties: Adherent
Primary citation: Létourneau et al. 2012. BMC Cancer. (12): 379. PMID: 22931248
Shipping conditions: Dry Ice
Growth medium: OSE medium contains 10% FBS, 0.5ug/mL amphotericin B and 50 ug/mL gentamicin
Atmosphere: Hypoxic condition of 5%O2 and 5%CO2
References:

Tomas et al. 2023. J Ovarian Res. 11

16(1):70. PMID: 37038202 Vias et al. 2023. Elife. 11

12:e83867. PMID: 37166279 Jubelin et al. 2022. Cell Biosci. 11

12(1):155. PMID: 36089610 Canals et al. 2022. Front Oncol. 4

12:856424. PMID: 35600398

Related Tools for Cell lines

Cat. # Tool Name
161768 TOV-1369TR cell line Key Info View Tool

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