MLL-AF9-miR-139 knock out cell line

MIR-139 is a critical tumor surpressor in AML

Contributors

Inventor Institute
Stefan Erkeland Erasmus Medical Center
SKU: 160880
Product description: MIR-139 is a critical tumor surpressor in AML
Alternate name: miR-139
Conditional: No
Production details: Lineage negative bone marrow cells were isolated from miR139 KO mice and transduced with MLL-AF9.
Parental cell line: Lineage negative bone marrow cells isolated from miR139 KO mice
Disease: Cancer
Cat. #: 160880
Cancer types: Blood cancer
Research Fields: Cancer
Organism: Mouse
Tissue: Bone Marrow
Model: Cancer Model
Growth properties: Enhanced Proliferation
Cancer Types In Detail: Acute Myeloid Leukaemia (AML)
Growth medium: As published in Stavast, C.J., van Zuijen, I., Karkoulia, E. et al. The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis. Leukemia 36, 687â?‚€?‚“700 (2022). https://doi.org/10.1038/s41375-021-01461-5
Recommended controls: MIR139 WT, MLL-AF9 cells
References:

Stavast et al. 2022. Leukemia. 36(3):687-700. PMID: 34741119.

Images

View Gallery
A Flow cytometric analysis of surface marker expression of MLL-AF9 or MLL-AF9-Mir139KO cells stained for myeloid lineage markers CD11b

Related Tools for Cell lines

Cat. # Tool Name
151484 2fTGH Cell Line Key Info View Tool
151631 C-Raf KI D486A Cell Line Key Info View Tool
151448 CMT 167 Cell Line Key Info View Tool
151503 1-7 CE1 Cell Line Key Info View Tool
151655 FLYA-13 Cell Line Key Info View Tool

Related News

UM-UC-10 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC), UK.
Cell Lines

Popular cell lines now available only from CancerTools.org

Read More
Cell Lines

New cell lines: murine melanocyte and melanoblast cell lines from Dr. Elena Sviderskaya

Read More
Image Reference: 2x PTEN -/- mouse prostate cancer cell lines (MuCap system). Histology staining of syngraft tumours (Van Duijn et al., 2018).
Cell Lines

38 new prostate cancer cell lines

Read More

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.