Cat. #161999
Melan-lnk4a-4 cell line
Cat. #: 161999
Organism: Mouse
Tissue: Skin
Disease: Non-cancer
Model: Immortalised non-cancerous cell lines
£575.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Elena Sviderskaya
Institute: St. George's University London
Primary Citation: Sviderskaya EV, et al. J Natl Cancer Inst. 2002 Mar 20;94(6):446-54. PMID: 11904317
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Melan-lnk4a-4 cell line
- Organism: Mouse
- Tissue: Skin
- Disease: Non-cancer
- Morphology: Small, oval-fusiform
- Model: Immortalised non-cancerous cell lines
- Description: The melan-Ink4a-1, -2, -3 and -4 cell lines are immortal melanocyte cell lines derived from the skin of neonatal Ink4a–/– C57BL/6J mice. These cells are p16Ink4a-null but Arf-competent. These cells are visibly pigmented and display morphology typical of normal melanocytes. In humans, INK4A is often inactivated in a range of cancers including melanoma. As a result, these melanocytes can be useful in studies focussing on skin cancers and melanomas.
- Application: Melanocyte cell biology
Applications
- Application: Melanocyte cell biology
Handling
- Growth medium: RPMI + FBS (10%) + TPA (200 nM) + CT (200 pM) + human stem cell factor (hSCF) (10 ng/ml) + endothelin-1 (EDN1) (10 nM)
- Storage conditions: liquid N2
References
- Sviderskaya EV, et al. J Natl Cancer Inst. 2002 Mar 20
- 94(6):446-54. PMID: 11904317
