Melan-ep2 cell line

Immortal melanocyte cell lines derived from neonatal Hps1ep/Hps1ep C57BL/6J mice

Contributors

Inventor Institute
Elena Sviderskaya St. George's University London
Cat. #: 162011
Organism: Mouse
Tissue: Skin
Model: Immortalised non-cancerous cell lines
Morphology: Small, oval-fusiform
Product description: The melan-ep1 and -ep2 cell lines are immortal melanocyte cell lines derived from neonatal Hps1ep/Hps1ep C57BL/6J mice. These cell lines lack ep (pale ear), a subunit of the biogenesis of lysosome-related organelles complex 3 (BLOC-3). BLOC-3 is involved in cargo recycling from melanosomes. Pathogenic variants in the human ortholog of ep, HPS1, cause a form of Hermansky-Pudlak syndrome (HPS), HPS type 1. HPS is a group of disorders characterised by hypopigmentation, bleeding tendency and other variable symptoms. These cells are a useful model for HPS and for the study of trafficking of cargoes towards lysosome-related organelles.
disease: Hermansky-Pudlak syndrome
Storage conditions: liquid N2
Growth medium: RPMI + FBS (10%) + TPA (200 nM) + cholera toxin (CT) (200 pM)

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