MEF OGG1 KO Cell Line

The MEF OGG1 KO cell line can be used to assess the role of the mammalian enzyme OGG1 in repair of DNA damage and prevention of carcinogenesis

Contributors

Inventor Institute
Tomas Lindahl Cancer Research UK, London Research Institute: Clare Hall Laboratories
Cat. #: 151846
Unit size: 1×10^6 cells / vial
Research Fields: Cancer;Drug development;Genetics
Organism: Mouse
Tissue: Embryo
Model: Knock-Out
Product description: The MEF OGG1 KO cell line can be used to assess the role of the mammalian enzyme OGG1 in repair of DNA damage and prevention of carcinogenesis. the cell line can be used to assess the incidence and consequences of 8-oxoG formation in the mammalian genome.
Cellosaurus ID: CVCL_6E74
Format: Frozen
Shipping conditions: Dry ice
Growth medium: DMEM/Ham's F-12 (3:1) with 10% FBS
References:

Klungland et al. 1999. Proc Natl Acad Sci U S A. 96(23):13300-5. PMID: 10557315.

Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage.

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