Cat. #162296
MDA-MB-468 TAp63 alpha TET-ON cell line
Cat. #: 162296
Organism: Human
Tissue: Pleural effusion of metastatic adenocarcinoma of the breast
Disease: Cancer
Model: Transgenic
£575.00
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Contributor
Inventor: Marta Nekulová
Institute: Masaryk Memorial Cancer Institute
Primary Citation: Nekulova et al. (2016). BMC Cancer, 10;16(1):782, PMID: 27724925
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: MDA-MB-468 TAp63 alpha TET-ON cell line
- Alternate name: MDA-MB-468 pcDNA6/TR pT-REX-DEST30-TAp63 alpha
- Parental cell: MDA-MB-468
- Organism: Human
- Gender: Female
- Tissue: Pleural effusion of metastatic adenocarcinoma of the breast
- Donor: 51 years old, black
- Disease: Cancer
- Morphology: Epithelial
- Growth properties: Adherent
- Model: Transgenic
- Model description: Conditional expression of TAp63? isoform of p63 protein after induction with tetracycline
- Conditional: Yes
- Conditional description: the TAp63? isoform of p63 protein is conditionally expressed after induction with tetracycline
- Description: MDA-MB-468 cell line expressing the TAp63? isoform of p63 protein after induction with tetracycline
- Application: Cell culture
Target Details
- Target: p63, isoform TAp63?
- Target background: TAp63? is a p63 isoform with oncogenic properties in epithelial cancers. TAp63? has multiple roles, such as inducing apoptosis or promoting cancer stem cells
Applications
- Application: Cell culture
Handling
- Format: Frozen
- Atmosphere: humidified CO2 atmosphere
- Storage conditions: Liquid Nitrogen
- Cultured in antibiotics: yes, penicillin/streptomycin
Related Tools
- Related tools: MDA-MB-468 delta Np63 alpha TET-ON (MDA-MB-468 pcDNA6/TR pT-REX-DEST30-delta Np63 alpha), MDA-MB-468 TET-ON (MDA-MB-468 pcDNA6/TR)
References
- Holcakova et al. (2017). Breast Cancer Res Treat. 163(3):475-484, PMID: 28349272
- Nekulova et al. (2016). BMC Cancer, 10
- 16(1):782, PMID: 27724925
