| Inventor | Institute |
|---|---|
| Jorgen Fogh | Memorial Sloan-Kettering Cancer Center (MSK) |
| SKU: | 161926 |
|---|---|
| Product description: | The Caov-3 cell line is a primary ovarian cancer cell line with epithelial morphology. These cells form tightly packed colonies in adherent culture. All-trans retinoic acid has been shown to suppress the growth of Caov-3 ovarian carcinoma cells in vitro. These cells express the NB/70K, CA-125, Ba-2, and Ca-1 tumour-associated antigens. The Caov-3 cells harbour a nonsense mutation in the p53 gene, and have multiple copies of the ovarian cancer oncogene PIK3CA. They are sensitive to vinblastine, cisplatin, and adriamycin. These cells fail to grow in soft agar but are tumourigenic when injected into immunocompromised mice. |
| Gender: | Female |
| Products or characteristics of interest: | Isoenzymes: AK-1, 1; ES-D, 1; G6PD, B; GLO-I, 1-2; Me-2, 2; PGM1, 1; PGM3, 1 |
| Cat. #: | 161926 |
|---|---|
| Cancer types: | Ovarian cancer |
| Organism: | Human |
| Tissue: | Ovary |
| Gender: | Female |
| Morphology: | Epithelial |
| Growth properties: | Adherent |
| Primary citation: | Buick et al. 1985. Cancer Research. 45: 3668-3676. PMID: 4016745. |
| Storage conditions: | Vapor phase of liquid nitrogen |
|---|---|
| Shipping conditions: | Dry Ice |
| Growth medium: | EMEM supplemented with FBS to a final concentration of 10% |
| Temperature: | 37° C |
| Atmosphere: | 5% CO2 in air |
| Storage medium: | Complete growth medium supplemented with 5% (v/v) DMSO |
| Biosafety level: | 1 |
| References: |
Yaginuma et al. 1992. Cancer Research. 52: 4196-4199. PMID: 1638534. Shayesteh et al. 1999. Nature Genetics. 21: 99-102. PMID: 9916799. |
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