Cat. #161926
Caov-3 Cell Line
Cat. #: 161926
Availability: 8-10 weeks
Organism: Human
Tissue: Ovary
£575.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Jorgen Fogh
Institute: Memorial Sloan-Kettering Cancer Center (MSK)
Primary Citation: Buick et al. 1985. Cancer Research. 45: 3668-3676. PMID: 4016745.
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Caov-3 Cell Line
- Cancer: Gynaecologic cancer
- Organism: Human
- Gender: Female
- Tissue: Ovary
- Donor: This cell line was established from the primary tumor of a 54-year-old Caucasian female with adenocarcinoma of the ovary.
- Morphology: Epithelial
- Growth properties: Adherent
- Products or characteristics of interest: Isoenzymes: AK-1, 1; ES-D, 1; G6PD, B; GLO-I, 1-2; Me-2, 2; PGM1, 1; PGM3, 1
- Description: The Caov-3 cell line is a primary ovarian cancer cell line with epithelial morphology. These cells form tightly packed colonies in adherent culture. All-trans retinoic acid has been shown to suppress the growth of Caov-3 ovarian carcinoma cells in vitro. These cells express the NB/70K, CA-125, Ba-2, and Ca-1 tumour-associated antigens. The Caov-3 cells harbour a nonsense mutation in the p53 gene, and have multiple copies of the ovarian cancer oncogene PIK3CA. They are sensitive to vinblastine, cisplatin, and adriamycin. These cells fail to grow in soft agar but are tumourigenic when injected into immunocompromised mice.
- Application: 3D cell culture
- Biosafety level: 1
Applications
- Application: 3D cell culture
Handling
- Growth medium: EMEM supplemented with FBS to a final concentration of 10%
- Temperature: 37° C
- Atmosphere: 5% CO2 in air
- Shipping conditions: Dry Ice
- Storage medium: Complete growth medium supplemented with 5% (v/v) DMSO
- Storage conditions: Vapor phase of liquid nitrogen
- Str profiling: Amelogenin: XCSF1PO: 10,13D13S317: 12D16S539: 9D5S818: 12D7S820: 10THO1: 7TPOX: 8,10vWA: 16,18
References
- Yaginuma et al. 1992. Cancer Research. 52: 4196-4199. PMID: 1638534.
- Shayesteh et al. 1999. Nature Genetics. 21: 99-102. PMID: 9916799.
