Caki-2 Cell line

Human Renal Cancer Cell Line. Caki-2 is a human clear cell renal cell carcinoma (ccRCC) line that displays epithelial morphology and grows in adherent culture. These cells are a useful preclinical model to study renal cancer. They are relatively less sensitive to 5-fluorouracil and sorafenib (multi-kinase inhibitor of VEGFRs 1-3, PDGFR-b, and Raf-1) compared to […]

Contributors

Inventor Institute
Jorgen Fogh, Germain Trempe Memorial Sloan-Kettering Cancer Center (MSK)
Cat. #: 161904
Cancer types: Renal cancer
Organism: Human
Tissue: Kidney
Gender: Male
Morphology: Epithelial
Growth properties: Adherent
Cancer Types In Detail: Clear cell carcinoma
Primary citation: Fogh J et al. 1977. Journal of the National Cancer Institute. 59: 221-226. PMID: 327080.
Product description: Human Renal Cancer Cell Line. Caki-2 is a human clear cell renal cell carcinoma (ccRCC) line that displays epithelial morphology and grows in adherent culture. These cells are a useful preclinical model to study renal cancer. They are relatively less sensitive to 5-fluorouracil and sorafenib (multi-kinase inhibitor of VEGFRs 1-3, PDGFR-b, and Raf-1) compared to Caki-1 cells. The Caki-2 cells have a loss-of-function mutation in the von Hippel-Lindau (VHL) tumour-suppressor protein and are known to form tumours in immunocompromised mice.
Gender: Male
Products or characteristics of interest: Karyotype: hypopentaploid to hypohexaploid (+A2, +A3, +B, +C, +D, +F, +G, -A) with abnormalities including dicentrics, acrocentric fragments, minutes, breaks, and large subtelocentric markers. Isoenzymes: AK-1, 1; ES-D, 1; G6PD, B; GLO-I, 1-2; Me-2, 1; PGM1, 1; PGM3, 1
Shipping conditions: Dry Ice
Growth medium: McCoy's 5a Medium Modified supplemented with 10% FBS
Temperature: 37° C
Storage medium: Complete growth medium supplemented with 5% (v/v) DMSO
Biosafety level: 1
References:

Fogh J et al. 1977. Journal of the National Cancer Institute 59: 221-226. PMID: 327080.

Miyake M et al. 2012. Oncology Letters. 3: 1195-1202. PMID: 22783417.

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