Caki-1 Cell Line

Human Renal Cancer Cell Line with epithelial morphology that was isolated from kidney tissue obtained from a 49-year-old white male patient with clear cell carcinoma. This cell line is a suitable transfection host and has applications in cancer and toxicology research. The cell line is aneuploid human, with chromosome counts in the triploid range. The […]

Contributors

Inventor Institute
Jorgen Fogh, Germain Trempe Memorial Sloan-Kettering Cancer Center (MSK)
Cat. #: 161903
Cancer types: Renal cancer
Organism: Human
Tissue: Kidney
Gender: Male
Morphology: Epithelial
Growth properties: Adherent
Cancer Types In Detail: Clear cell carcinoma
Primary citation: Fogh et al. 1977. Journal of the National Cancer Institute. 59: 221-226. PMID: 327080.
Product description: Human Renal Cancer Cell Line with epithelial morphology that was isolated from kidney tissue obtained from a 49-year-old white male patient with clear cell carcinoma. This cell line is a suitable transfection host and has applications in cancer and toxicology research. The cell line is aneuploid human, with chromosome counts in the triploid range. The Y chromosome is absent; however, loss of the Y chromosome is not unusual from male tumour cell lines. All normal autosomes except chromosome N9 and N19 are represented, usually by two or three copies. Chromosome N9 is recognised as a marker chromosome (M1) that is usually trisomic. Normal chromosome N5 is and chromosomes N10 and N16 tend to be over-represented with respect to the copy number of other normal chromosomes. Thirteen marker chromosomes are identified: 9q+, t(1p;?), t(1qter>1q21::20), t(1q17q), der(11)t(3;11)(q21;q14), 19q+, 4q+, 4p+ and others. 
Gender: Male
Products or characteristics of interest: Isoenzymes, AK-1, 1; ES-D, 1-2; G6PD, B; GLO-I, 1-2; Me-2, 2; PGM1, 1; PGM3, 1-2;
Shipping conditions: Dry Ice
Growth medium: McCoy's 5a Medium Modified supplemented with 10% FBS
Temperature: 37° C
Biosafety level: 1
References:

Fogh et al. 1977. Journal of the National Cancer Institute. 59:221-226. PMID: 327080.

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