C2.2.2 cell line

Spontaneous vemurafenib resistant A375 Melanoma Clones

Contributors

Inventor Institute
Christoper Stipp University Of Iowa Research Foundation
Cat. #: 161800
Cancer types: Skin cancer
Research Fields: Cancer;Drug development
Organism: Human
Tissue: Skin
Gender: Female
Morphology: Compact Morphology
Primary citation: Feddersen et al.2019. Cancer Res. 79(19). PMID: 31416852
Alternate name: C2.2.2
Product description: Spontaneous vemurafenib resistant A375 Melanoma Clones. Shows frequent alterations of BRAF^V600 protein. No increased VAV1 protein levels. Increased MEK Phosphorylation on S298 (Pak Site).
Gender: Female
Production details: Long-term cultures of A375 cells in 3 ?M vemurafenib. Spontaneous vemurafenib-resistant clones and populations were created after 2–3 and 4–6 weeks cultured in 3 mm vemurafenib. Maintained in media with 3 mm vemurafenib.
Parental cell line: A375 Melanoma (ATCC)
Growth medium: DMEM(Gibco) suplemented with penicillin/streptomycin (Gibco) and 10% FBS (Gibco).
References:

Feddersen et al.2019. Cancer Res. 79(19).PMID: 31416844

Zhu et al. 2022. npj Precis. Onc. PMID: 36271150

Related Tools for Cell lines

Cat. # Tool Name
151445 1-7HB2 Cell Line Key Info View Tool
151449 JIM1 Cell Line Key Info View Tool
151503 1-7 CE1 Cell Line Key Info View Tool
151576 MEF RAF1 KO Cell Line Key Info View Tool
151665 MEF PKCe KO Cell Line Key Info View Tool

Related News

UM-UC-10 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC), UK.
Cell Lines

Popular cell lines now available only from CancerTools.org

Read More
Cell Lines

New cell lines: murine melanocyte and melanoblast cell lines from Dr. Elena Sviderskaya

Read More
Image Reference: 2x PTEN -/- mouse prostate cancer cell lines (MuCap system). Histology staining of syngraft tumours (Van Duijn et al., 2018).
Cell Lines

38 new prostate cancer cell lines

Read More

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.