Plasmax™ cell culture medium

Physiologically relevant cell culture medium

Contributors

Inventor Institute
Saverio Tardito CRUK Scotland Institute
Cat. #: 156371
Tool sub type: Cell culture media
Unit size: 500 ml
Application: Cell culture; Cell growth and viability
Volume: 500 ml
Purpose: Physiologically relevant cell culture medium which mimics the metabolic and physiological profile of human plasma
Formulation: Complete and ready-to-use cell culture medium. For the formulation, please, see Documentation
Primary citation: Vande Voorde et al. 2019. Sci Adv. 5(1):eaau7314. PMID: 30613774
Alternate name: Plasmax™
Product description: Plasmax™ is a new physiologically relevant cell culture medium which mimics the metabolic and physiological profile of human plasma. It is designed to improve the metabolic fidelity and biological relevance of in vitro cancer models by recapitulating the natural in vivo metabolic environment in an in vitro setting. Researchers have found that conventional growth-focused media with non-physiological concentrations of nutrients and metabolites can skew the metabolic profile of cancer cells. Plasmax™ is optimised from over 80 components, including amino acids and derivatives, inorganic salts, trace elements, and vitamins, of which over 50 are at levels found in human plasma. Plasmax™ is also the only ready-to-use cell culture media containing growth-enhancing trace elements including vanadium, zinc, manganese, copper and selenium. Plasmax™ can be used by cancer researchers interested in cancer cell biology. It has been successfully validated across a broad range of cells – both primary and established cell lines from different tissues, species and in various experimental conditions.
Application: Cell culture; Cell growth and viability
Application notes: Have a question about Plasmax™? See some frequently asked questions in our Plasmax FAQs in the FAQ section of the website. Please see the Plasmax™ Material Safety Data Sheet (MSDS) in the documentation section below.
References:

Tepp et al. 2025. Environ Toxicol Pharmacol. 115:104675. PMID: 40097081.

Taba et al. 2025. Antioxidants (Basel). 14(2):137. PMID: 40002325.

Alva et al. 2024. Biochem Biophys Res Commun. 742:151108. PMID: 39632288.

Lahtinen et. al. 2023. Cancer Cell. 41(6):1103-1117.e12. PMID: 37207655.

Avellino et al. 2023. Am J Physiol Cell Physiol. 324(4):878-885. PMID: 36878843.

Villar et al. 2023. Nat Chem Biol. 19(3):292-300. PMID: 36280791.

Gassl et al. 2022. Cancers (Basel). 14(22):5617. PMID: 36428711.

Wang et al. 2022. Biomolecules. 12(11):1575. PMID: 36358924.

Gardner et al. 2022. Am J Physiol Cell Physiol. 323(3):C823-C834. PMID: 35876286.

Golikov et al. 2022. Mol Biol (Mosk). 56(5):687-696. PMID: 36165010.

Taurino et al. 2022. Mol Metab. 101532. PMID: 35752287.

Wang et al. 2022. Biomolecules. 12(6):743. PMID: 35740868.

Bagshaw et al. 2021. Biomater Biosyst. 4:100027. PMID: 36824572.

Golikov et al. 2022. Antioxidants (Basel). 11(1): 97. PMID: 35052601.

Kalimuthu et al. 2021. J Cell Biochem. 123(3):532-542. PMID: 34935169.

Hennequart et al. 2021. Natu Commun. 12(1):6176. PMID: 34702840.

Chiu et al. 2021. Blood Adv. 5(23):5164-5178. PMID: 34614505.

Cox et al. 2020. JDIS. 5(3): 161-177.

Moradi et al. 2021. Biomolecules. 11(8):177. PMID: 34439843.

Barekatain et al. 2021. Nat Commun. 12(1):4228. PMID: 34244484.

Moradi et al. 2021. Am J Physiol Cell Physiol. 321(1):C72-C81. PMID: 34010067.

Khadka et al. 2021. Cancer Metab. 9(1):27. PMID: 34172075.

Abbas et al. 2021. Comp Biochem Physiol B Biochem Mol Biol. 254:110570. PMID: 33516822.

Ackermann et al. 2019. Trends Cancer. 5(6):329-332. PMID: 31208694.

Vande Voorde et al. 2019. Sci Adv. 5(1). PMID: 30613774.

Images

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Plasmax™ bottle
Validation of Plasmax™ growth performance compared to DMEM. Unpublished data. Similar data including growth can be found in PMID: 30613774.
Comparison of the formulation of Plasmax™ cell culture medium and DMEM-F12. Adapted from PMID: 30613774.

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